• See current chronic leukaemia trials

Research trials are carried out to try to find new and better treatments for leukaemia. Trials that are carried out on patients are known as clinical trials.

Clinical trials may be carried out to:

• test new treatments, such as new chemotherapy drugs, gene therapy or cancer vaccines
• look at new combinations of existing treatments, or change the way they are given, to make them more effective or to reduce side effects
• compare the effectiveness of drugs used for symptom control
• find out how cancer treatments work
• see which treatments are the most cost-effective.

Trials are the only reliable way to find out if a different or new treatment is better than what is already available.

Taking part in a trial

You may be asked to take part in a treatment research trial. There can be many benefits in doing this. Trials help to improve knowledge about leukaemia and develop new treatments. You will also be carefully monitored during and after the study. Usually, several hospitals around the country take part in these trials. It is important to bear in mind that some treatments that look promising at first are often later found not to be as good as existing treatments, or have side effects that outweigh the benefits.

If you decide not to take part in a trial your decision will be respected and you do not have to give a reason. There will be no change in the way that you are treated by the hospital staff and you will be offered the standard treatment for your situation.

Blood and tumour samples

Many blood samples and bone marrow biopsies may be taken to find out what is wrong with you. Most of these are needed to make the right diagnosis. You may be asked for your permission to use some of your samples for research into cancer. Some samples may be frozen and stored for future use, when new research techniques become available.

The research may be carried out at the hospital where you are treated, or it may be at another hospital. This type of research takes a long time, so you are unlikely to hear the results. The samples will, however, be used to increase knowledge about the causes of cancer and its treatment. This research will, hopefully, improve the outlook for future patients.

Current research

One trial, called SPIRIT, aims to see whether different doses of imatinib (Glivec®), or a combination of imatinib and interferon, are better for people with newly-diagnosed chronic phase CML. Another trial is also looking at different ways of giving imatinib, and combining it with the growth factor G-CSF.

Two biological therapy drugs that are similar to imatinib are being researched as possible treatments for people with CML. These are called dasatinib and nilotinib. Both of these treatments are taken orally. Early research trials have shown that they can help to control CML in people who have already been treated with imatinib.