Peripheral T-cell lymphoma is one type of non-Hodgkin lymphoma (NHL). From a practical viewpoint doctors divide all the various types of NHL into one of three groups: low grade, high grade or intermediate grade. This division is based on the appearances under the microscope and helps predict how the condition will behave.

Low grade NHLs usually have a relatively slow growth rate, running a long course and often needing little or no treatment for months or possibly years. When they do need treatment they respond well but are likely to come back again at some time in the future. They frequently respond to treatment on several occasions over the years but may eventually become resistant or transform to a high grade form of NHL.

High grade types of NHL usually grow more rapidly and behave more aggressively and so need immediate treatment. Despite this they are more likely to be completely cured than low grade NHLs. Around half of all people with high grade forms of NHL will be cured by the use of intensive chemotherapy.

Intermediate types of NHL lie somewhere between these two extremes in their behaviour.

Peripheral T-cell lymphoma behaves as a high-grade, or more aggressive lymphoma and requires prompt treatment.

Chemotherapy is the treatment of choice for peripheral T-cell lymphomas. Unfortunately although a variety of different drug combinations have been used cure is not possible in the majority of people. This means that a number of clinical trials are in progress to try and improve the results of treatment.

Although a cure is not usually possible moderately intensive chemotherapy can often reduce and control the condition for a period of time.